Brandt Pence, PhD

Assistant Professor

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Brandt D Pence 0781 UofM TC 20190402 V.j

Contact: bdpence@memphis.edu

Research Interests:

  • Regulation of monocyte and macrophage metabolism, inflammatory responses, and function by aging

  • Molecular links between cellular senescence, inflammaging, and immunosenescence

  • Function and phenotype of senescent monocytes and macrophages

  • Immunometabolic regulation of atherosclerosis

  • Macrophage and monocyte contributions to pathogenesis of SARS-CoV-2 and COVID-19

  • Exercise and nutritional interventions to promote immune health

Technical Expertise:

  • Seahorse extracellular flux assays

  • Flow cytometry

  • Monocyte and macrophage functional studies

  • Cellular immunology (qPCR, ELISA, immunofluorescence, etc.)

Affiliated Programs:

Funding:

  • American Heart Association

  • Etc.

Key Publications:

  • Pence BD. Severe COVID-19 in aging: are monocytes the key? Geroscience 42: 1051-1061, 2020.
    doi: 10.1007/s11357-020-00213-0

  • Yarbro JR, Pence BD. Classical monocytes from older adults maintain capacity for metabolic compensation during glucose deprivation and lipopolysaccharide stimulation. Mechanisms of Ageing and Development 183: 111146, 2019.
    doi: 10.1016/j.mad.2019.111146

  • Etc.

  • Etc.