Brandt Pence, PhD

Research Interests:

• Regulation of monocyte and macrophage metabolism, inflammatory responses, and function by aging

• Molecular links between cellular senescence, inflammaging, and immunosenescence

• Function and phenotype of senescent monocytes and macrophages

• Immunometabolic regulation of atherosclerosis

• Macrophage and monocyte contributions to pathogenesis of SARS-CoV-2 and COVID-19

• Exercise and nutritional interventions to promote immune health

​

Technical Expertise:

• Seahorse extracellular flux assays

• Flow cytometry

• Monocyte and macrophage functional studies

• Cellular immunology (qPCR, ELISA, immunofluorescence, etc.)

​

Affiliated Programs:

• University of Memphis, Master of Science in Nutrition Science

• University of Memphis, Master of Science in Exercise, Sport & Movement Science

​

Funding:

• American Heart Association

• Etc.

​

Key Publications:

• Pence BD. Severe COVID-19 in aging: are monocytes the key? Geroscience 42: 1051-1061, 2020.
  doi: 10.1007/s11357-020-00213-0

• Yarbro JR, Pence BD. Classical monocytes from older adults maintain capacity for metabolic compensation during glucose deprivation and lipopolysaccharide stimulation. Mechanisms of Ageing and Development 183: 111146, 2019.
  doi: 10.1016/j.mad.2019.111146

• Etc.

• Etc.

​

​

​

​